What Loperamide Doses Help with Opiate Withdrawal?

Loperamide is the pharmaceutical name for the brand name over-the-counter medication Imodium. It is used to control diarrhea and flatulence. People who abuse opioids like heroin and prescription painkillers such as OxyContin, Percocet, Roxicet, Vicodin, and others try to use massive amounts of loperamide to lower or minimize opioid withdrawal symptoms. 

Opioid addiction causes changes to occur in a person’s brain and neurochemistry. When a person becomes addicted to an opioid, their bodies adjust to the presence of opioids in their system. The longer a person remains on an opioid drug or medication, they will not function physically without ingesting opioids regularly. If they try to stop, then painful opioid withdrawal symptoms set in. Many have learned that loperamide can possibly help with this. But at what doses does loperamide help with opiate withdrawal symptoms?

What Loperamide Doses Help with Opiate Withdrawal?

What Are Symptoms of Opioid Addiction?

Opioid addiction can develop in a short amount of time. If a person uses their prescription pain killers every day for only one month, they will experience withdrawal symptoms when they stop using them. Similarly, heroin or illegal opioid drugs will also cause the same withdrawal symptoms after only one month of use. The symptoms that occur during opioid withdrawal are serious. Most people addicted to heroin or prescription opioids remain on their drug of choice for many years because they do not want to experience withdrawals.

The longer a person uses opioids, the worse their withdrawal symptoms will become. They must use opioids regularly and a lot of them. If they do not keep a steady stream of opioids in their blood, they will experience the following within as few as 4 to 6 hours after their last dose or use:

  • Sweating and fever chills
  • Cold and flu-like symptoms (sneezing, runny nose, cough)
  • Diarrhea and vomiting
  • Muscle spasms and body aches
  • Agitation and anxiety
  • Severe insomnia
  • Rapid heart rate and heart palpitations
  • Intense cravings for an opioid drug
  • An inability to function- generally

Does Loperamide Work for Opioid Withdrawal?

The bottom line that everyone wants to know is, does loperamide work for opioid withdrawal symptoms? People with an addiction to opioids have discovered that large doses of loperamide can help with opiate withdrawal symptoms to a reasonable level so they can be physically able to go and get more of their preferred opioid, or go through the detox themselves. This is NOT advised, medically dangerous, and can cause SERIOUS side effects to your or a loved one’s health. 

The reason that loperamide can help with opiate withdrawal symptoms is because loperamide acts on the same opioid receptors in the brain that other opioid drugs like heroin or prescription painkillers affect. Massive amounts of Loperamide acts like an opioid, but its chemical structure is not similar to common opioids. Therefore, it does not cross the blood-brain barrier, which is what causes euphoria and addiction. On the other hand, many people ask what does of loperamide can help with opiate withdrawal symptoms, and there is no clear clinical answer, because no FDA-approved studies were done on this.

Is Loperamide Dangerous At Large Doses for Opioid Detox Symptoms?

When a person relies on loperamide to prevent opioid withdrawal, the dangers that exist are incredibly detrimental and can even lead to death. The National Center for Biotechnology Information advances in science and health has stated how the problem of loperamide misuse and abuse is growing and what occurs when someone ingests large amounts of Loperamide:  

Cardiac complications following a loperamide overdose are a growing concern for patients presenting to the emergency department. Loperamide (Imodium®) is an over-the-counter anti-diarrheal medication abused by some patients to either achieve opioid-like euphoria or self-medicate the symptoms of opioid withdrawal. The use of this drug of abuse is on the rise, with the number of cases of reported overdose increasing each year. (NCBI)

 The cardiac conditions that Loperamide causes when taken in large amounts can quickly kill a person. The quantity of Loperamide that most opioid addicts have reported using to calm their withdrawal systems is toxic. Medical reports have documented that opioid addicts are taking upwards of 200 mg to 400 mg of Loperamide. Loperamide’s regular doses to help control diarrhea are to take one 4mg dose and only repeat 2mg doses every few hours and not exceed 16 mg in 24 hours.

The Amount of Loperamide Needed to Minimize Opiate Withdrawal

The cost to ingest 200mg to 400mg of Loperamide, as Imodium AD, is also expensive. One package of Imodium AD for 24 tablets or capsules that come with 2mg each runs about $15.00. To get up to 200 or 400 mg, a person would need to buy eight packages roughly, which costs $120.00 just for ONE DOSE to ward off withdrawal symptoms temporarily.

These vast amounts of Loperamide will cause a severe heart rhythm condition that can potentially cause fast, chaotic heartbeats, known as QT syndrome. The symptoms of this syndrome will include sudden fainting, seizures, or even sudden death. Since Loperamide is dangerous and expensive to help relieve opioid withdrawal symptoms, it seems absurd that anyone would choose this option. However, addiction to opioids is one of the most devastating in limiting individuals to their physical dependence on opioids.  

Opioid addiction will cause a person to steal, harm others physically, rob their grandparents, and use massive amounts of Loperamide to feel better. The programs that we connect clients can provide you or a loved one fast relief from their opioid withdrawal symptoms with safe and effective medications. The centers we send clients to for opioid detox can admit you or a loved one immediately. Call one of our representatives to begin safe opioid replacement medications right now.


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